{"id":6919,"date":"2024-07-20T10:02:29","date_gmt":"2024-07-20T07:02:29","guid":{"rendered":"https:\/\/www.bursacocukkardiyoloji.com\/?p=6919"},"modified":"2024-07-21T08:16:56","modified_gmt":"2024-07-21T05:16:56","slug":"yasamin-erken-donemlerinde-antibiyotik-kullanimi-alerji-ve-astim-gelistirme-riskini-artirir","status":"publish","type":"post","link":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/2024\/07\/20\/yasamin-erken-donemlerinde-antibiyotik-kullanimi-alerji-ve-astim-gelistirme-riskini-artirir\/","title":{"rendered":"Ya\u015fam\u0131n erken d\u00f6nemlerinde antibiyotik kullan\u0131m\u0131 alerji ve ast\u0131m geli\u015ftirme riskini art\u0131r\u0131yor !&#8230;"},"content":{"rendered":"\n<p>Ya\u015fam\u0131n erken d\u00f6nemlerinde antibiyotik kullan\u0131m\u0131 barsak mikrobiyal kolonizasyonu bozarak alerji ve ast\u0131m geli\u015ftirme riskini art\u0131rmaktad\u0131r.  <\/p>\n\n\n\n<p><strong>Olaf Perdijk ve ark<\/strong>.&#8217; \u0131n\u0131n yapt\u0131klar\u0131 bir \u00e7al\u0131\u015fmada ya\u015fam\u0131n erken d\u00f6nemlerinde antibiyotik verilen farelerin, ev tozu akar\u0131 kaynakl\u0131 alerjik hava yolu iltihab\u0131na kar\u015f\u0131 daha duyarl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Bu duyarl\u0131l\u0131\u011f\u0131n, ba\u011f\u0131rsak mikrobiyomunun normale d\u00f6nmesinden sonra bile devam etti\u011fi saptanm\u0131\u015ft\u0131r. <\/p>\n\n\n\n<div class=\"wp-block-essential-blocks-advanced-image  root-eb-advanced-image-8xm4x\"><div class=\"eb-parent-wrapper eb-parent-eb-advanced-image-8xm4x \"><figure class=\"eb-advanced-image-wrapper eb-advanced-image-8xm4x img-style-rounded caption-style-1 caption-horizontal-center caption-vertical-bottom bottom no-effect\" data-id=\"eb-advanced-image-8xm4x\"><div class=\"image-wrapper\"><img decoding=\"async\" src=\"https:\/\/www.bursacocukkardiyoloji.com\/wp-content\/uploads\/2024\/07\/fx1_lrg.jpeg\" alt=\"\"\/><\/div><\/figure><\/div><\/div>\n\n\n\n<p>Ya\u015fam\u0131n erken d\u00f6nemlerinde kullan\u0131lan antibiyotik, akci\u011fer epitelinde h\u00fccresel stres, metabolizma ve mitokondriyal solunumda uzun vadeli de\u011fi\u015fikliklere neden olan <strong>indol-3-propiyonik asit (IPA)<\/strong>&#8216;n\u0131n sistemik d\u00fczeylerini d\u00fc\u015f\u00fcrmektedir. D\u00fc\u015fen IPA, mitokondriyal solunumu ve s\u00fcperoksit \u00fcretimini azaltmakta, kemokin ve sitokin \u00fcretimini de\u011fi\u015ftirmektedir. Ya\u015fam\u0131n erken d\u00f6nemlerinde IPA takviyesi, erken d\u00f6nem antibiyotik kullan\u0131lan fareleri yeti\u015fkinlikte ev tozu akar\u0131 kaynakl\u0131 alerjik hava yolu iltihab\u0131n\u0131n \u015fiddetlenmesine kar\u015f\u0131 korumaktad\u0131r. <\/p>\n\n\n\n<p>Bu sonu\u00e7lar, ya\u015fam\u0131n erken d\u00f6nemlerinde kullan\u0131lan antibiyotiklerin, akci\u011feri alerjik hava yolu iltihab\u0131na yatk\u0131n hale getirebilece\u011fi bir mekanizmay\u0131 ortaya koymakta ve erken d\u00f6nemlerinde kullan\u0131lan antibiyotiklerin zararl\u0131 sonu\u00e7lar\u0131n\u0131 hafifletmek i\u00e7in olas\u0131 bir \u00f6nleyici yakla\u015f\u0131m\u0131 da beraberinde vurgulamaktad\u0131r.<\/p>\n\n\n\n<p>Perdijk O, Butler A, Macowan M, Chatzis R, Bulanda E, Grant RD, Harris NL,<br>Wypych TP, Marsland BJ. Antibiotic-driven dysbiosis in early life disrupts<br>indole-3-propionic acid production and exacerbates allergic airway inflammation<br>in adulthood. Immunity. 2024 Jul 6:S1074-7613(24)00316-9.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ya\u015fam\u0131n erken d\u00f6nemlerinde antibiyotik kullan\u0131m\u0131 barsak mikrobiyal kolonizasyonu bozarak alerji ve ast\u0131m geli\u015ftirme riskini art\u0131rmaktad\u0131r. Olaf Perdijk ve ark.&#8217; \u0131n\u0131n yapt\u0131klar\u0131 bir \u00e7al\u0131\u015fmada ya\u015fam\u0131n erken d\u00f6nemlerinde antibiyotik verilen farelerin, ev tozu akar\u0131 kaynakl\u0131 alerjik hava yolu iltihab\u0131na kar\u015f\u0131 daha duyarl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Bu duyarl\u0131l\u0131\u011f\u0131n, ba\u011f\u0131rsak mikrobiyomunun normale d\u00f6nmesinden sonra bile devam etti\u011fi saptanm\u0131\u015ft\u0131r. Ya\u015fam\u0131n erken d\u00f6nemlerinde kullan\u0131lan antibiyotik, akci\u011fer epitelinde [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6923,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-6919","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/posts\/6919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/comments?post=6919"}],"version-history":[{"count":4,"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/posts\/6919\/revisions"}],"predecessor-version":[{"id":6929,"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/posts\/6919\/revisions\/6929"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/media\/6923"}],"wp:attachment":[{"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/media?parent=6919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/categories?post=6919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bursacocukkardiyoloji.com\/index.php\/wp-json\/wp\/v2\/tags?post=6919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}